Disease Ecology Seminar: Mary Bushman

"Within-Host Competition and Evolution of Drug Resistance in Malaria," Mary Bushman, postdoctoral fellow at Emory University.

Abstract: The malaria parasite Plasmodium falciparum has evolved resistance to virtually every antimalarial drug in existence. Curiously, although sub-Saharan Africa accounts for roughly 90% of the global burden of malaria, drug resistance has seldom emerged locally within Africa. Instead, resistance mutations have most often appeared in low-transmission settings, such as Southeast Asia, and later spread into Africa by gene flow. One hypothesis to explain this pattern is that drug-resistant mutants face more intense and frequent competition in high-transmission settings, where the prevalence of infection is high, and that this competition inhibits the establishment and spread of resistance. In this talk, I will present empirical and theoretical results showing that (1) within-host competition occurs in P. falciparum and that (2) this competition may help to explain global patterns of drug resistance evolution in malaria. 

 

Friday, September 6, 2019 at 3:00pm to 4:00pm

Ecology Building, Seminar Room 117
140 E Green Street, Athens, GA 30602

Event Type

Lectures and Discussions

Audience

Current Students, Faculty & Staff, Community

Topic

Research, Science & Technology

Website

https://mailchi.mp/9d37a0ee6c7a/disea...

Cost

Free, RSVP Requested

Group
Center for Tropical and Emerging Global Diseases (CTEGD), Center for the Ecology of Infectious Diseases
Department
School of Ecology
Hashtag

#CEID

Event Contact Name

Trippe Ross

Event Contact Phone Number

706-542-1930

Event Contact Email

tross312@uga.edu

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