Disease Ecology Seminar: Mary Bushman
"Within-Host Competition and Evolution of Drug Resistance in Malaria," Mary Bushman, postdoctoral fellow at Emory University.
Abstract: The malaria parasite Plasmodium falciparum has evolved resistance to virtually every antimalarial drug in existence. Curiously, although sub-Saharan Africa accounts for roughly 90% of the global burden of malaria, drug resistance has seldom emerged locally within Africa. Instead, resistance mutations have most often appeared in low-transmission settings, such as Southeast Asia, and later spread into Africa by gene flow. One hypothesis to explain this pattern is that drug-resistant mutants face more intense and frequent competition in high-transmission settings, where the prevalence of infection is high, and that this competition inhibits the establishment and spread of resistance. In this talk, I will present empirical and theoretical results showing that (1) within-host competition occurs in P. falciparum and that (2) this competition may help to explain global patterns of drug resistance evolution in malaria.
Friday, September 6, 2019 at 3:00pm to 4:00pm
Ecology Building, Seminar Room 117
140 E Green Street, Athens, GA 30602