Disease Ecology Seminar: Cara Brook
"Understanding bats as reservoirs for emerging viral zoonoses," Cara Brook, Miller Postdoctoral Fellow at U.C. Berkeley.
Abstract: Bats are reservoirs for the world's most virulent viral zoonoses, including Ebola and Marburg filoviruses and Hendra and Nipah henipaviruses, pathogens which they host without exhibiting symptoms of clinical disease. Recent molecular advances suggest that the evolution of flight may have promoted the development of anti-inflammatory physiologies allowing bats to effectively mitigate oxidative stress accrued during metabolism--with cascading consequences for longevity and viral tolerance. Dr. Brook's research investigates ecological and evolutionary questions in the bat-virus system, exploring the mechanisms enabling bat virus persistence at the population level, as well as the impacts of unique bat immune strategies on the probability of between-host viral transmission and the evolution of within-host viral virulence. Dr. Brook combines field studies focused on longitudinally-monitored fruit bat populations in central Madagascar with in vitro experiments in bat tissue culture and theoretical adaptive dynamics approaches to explore questions related to the persistence, evolution, and emergence of zoonotic viruses from bat reservoir hosts.
Wednesday, October 2, 2019 at 12:10pm to 1:20am
Ecology Building, 117
140 E Green Street, Athens, GA 30602